If Dredge Line deals the killing blow, it will drag Nautilus to where the target was upon death, as if the skill had hit terrain.
Titan's Wrath and Riptide are excellent farming tools when used together, as they each deal a good amount of area of effect damage.
Titan's Wrath resets your autoattack timer, so timing it right after a basic attack can allow for a quick second hit.
Despite Titan's Wrath bonus on-hit damage will be lost upon depletion or expiry of the shield, if Nautilus' attack animation is in first half of modified animation, his next hit will trigger the on-hit magic DoT as well.
If you are farming minions, Staggering Blow can be a great tool to increase your last-hitting capabilities due to its free bonus-damage.
Be careful when chasing an enemy under the turret with Dredge Line. If you miss and hit the turret, you'll end up horribly off position.
Be sure about your position while using Riptide. You must be close enough to catch the opponent because this spell is pretty slow in animation.
The range onDredge Line is a bit further than the indicator shows. Experiment on terrain to see how far you can be to proc the skill shot.
Dredge Line is a fantastic method of travel, especially at higher levels. When running around between lanes, use it on terrain to pull yourself along faster. The same goes for fleeing; if a fight goes bad, run for the nearest turret or open terrain, and pull yourself to it for a quick escape. For a quick start after recalling or respawning, latch on to your nexus.
To perform the highest crowd control/burst combo on a target send Depth Charge after them. Right when the opponent is in landing back to the ground follow up with an easy Dredge Line and a mid-air Riptide to ensure a second explosions hit. Finally hit them for Staggering Blow and use Titan's Wrath for the autoattack rest, bonus damage and absorbing counter-attack
Mark squishy/high priority targets with Depth Charge in order to give your team a good chance to kill them. It's also useful for stopping channels, such as Death LotusKatarina. Also, the squishy targets tend to be at the back their team so you'll be able to hit their entire team with the pass through damage instead of only one target with the explosion damage
Remember that Staggering Blow is an immobilization, which means it does nothing to stop channeled ultimates.
If you use Dredge Line on terrain right before any cc like Blitzcrank's Rocket Grab hits you, then you will still pull yourself to the terrain if your hook hit the terrain after the enemy's cc hits, practically mitigating the cc. (e.g. Blitz pulls you but midway the hook you cast beforehand hits terrain, so instead of flying to blitz you pull yourself to the terrain your hook hit.) Use this tactic to escape any enemy champion with a form of cc, as after you pull yourself they have nothing to stop you. keep in mind though cc like stuns will still take effect, you will just pull yourself away to increase distance.
Attack speed can speed up jungling by increasing the amount of damage your Titan's Wrath does over time, since each attack immediately applies the first tick of the damage over time.
Nautilus can jungle because Titan's Wrath and Riptide are extremely effective for clearing out minion camps.
Building resistances will generally give your shield more effective health than building health, despite the health ratio on it.
Abyssal Scepter helps both in tanking and increasing your damage, especially since Nautilus is such a good initiator and often in the middle of the enemy team's zone in fights.
Nautilus has really high ability power ratios for a tank, making one or two tanky mage items desirable on him. Rod of Ages offers a good deal of health and ability power. Its build path item Catalyst the Protector solves Nautilus' mana problems when he does not have the Crest of the Ancient Golem.
On games when you are far ahead you can consider odd item picks like Zhonya's Hourglass or Morellonomicon just to further stomp over your weakened enemy team. It's worth noting that Nautilus gets outrageously bursty with some ability power.
While Warmog's Armor does increase the damage amount absorbed by Titan's Wrath it doesn't increase your overall damage output, making the enemy less likely to focus you during fights.
Iceborn Gauntlet offer a lot of different stats, all of which Nautilus really likes. The slow field that it creates adds even more disruption and crowd control to Nautilus' already overloaded kit, making it very desirable.
Randuin's Omen gives a lot of health, a world of armor and gifts Nautilus with an extra CC ability to use while he is suffering from his long cooldowns.
Nautilus depends greatly on his abilities to deal damage so building CDR to counter his large cooldowns will allow you to do great amounts of damage to the enemy team.
Spirit Visage and Frozen Heart are simply perfect, allowing him to get really tanky while solving his cooldown problems, not to mention that their build paths are really easy and already give useful stats
Fiendish Codex and its upgrades greatly benefit a more damage-oriented style of gameplay.
Wit's End is a good item on Nautilus if he gets an early advantage it allows him to deal a good amount of magic damage with Titan's Wrath and also helps him clear the jungle faster.
Titan's Wrath has a very long CD time, especially early before Nautilus gets it to high levels and has more CDR. Try running out the clock on the ability, then hit him during that cooldown window.
Titan's Wrath can add up to significant damage over the course of a team fight. Consider diverting a couple of attacks to break the shield when you see him use it.
Nautilus can be used as a CC heavy support like Leona with a harder to land initiation but with more damage and CC, getting caught by his combo and his lane partner can be even deadlier than getting grabbed by Blitzcrank.
Nautilus is one of the few tanks that has strong magic damage, so consider building magic resistance.
While Nautilus has burst damage, this is moot when his abilities are on cooldown. Try to engage him after he has used several abilities.
Dredge Line draws Nautilus to terrain, so when running from him, try and stay away from terrain, or a miss may still bring him closer.
With enough ability power Nautilus can burst down a squishy target (ADC, APC) like a mage, but including an overwhelming amount of CC
He will combo with Dredge Line, followed by Riptide (that will likely hit twice), all while he has his shield up, and finish the it landing an unavoidable Depth Charge , that has even more harsher CC and a devastating blow of damage.
Nautilus will think twice of following the attack if you avoid Dredge Line, as it will be much harder for him to combo, and Dredge Line has quite a damaging blow, that Nautilus can't hope to miss, as he is just left with Depth Charge to close the gap, and losing a significant amount of damage.
Nautilus has early mana problems, force him to overuse his abilities.
Stand still when he uses his Riptide to prevent the extra magic damage the spell deals when it moves.
Even standing still it's very likely to get hit by two explosions if you are using any champion bigger than Teemo or Lulu
Getting hit by 3 explosions is impossible if you are still but almost confirmed to hit if you are moving.