- Syndra was designed by Meddler .
- Syndra was originally named "Sym" .
- Syndra shares the voice actress of , however, the voice actress has never been publically revealed or credited and is anonymous.
- Syndra is the first official champion to directly manipulate minions and neutral monsters to deal damage to other champions, moving them around with her abilities.
- Syndra's spheres appear as red instead of blue when on the opposing team. She is the fourth champion to have team perspective based particles, with the third being , the second being and the first being .
- Using Force of Will to hit an enemy unit with the will apply the debuff on them. Also, if Syndra throws the , she will be refunded 10 mana and the ability's cooldown will be lowered by 1 second.
- Syndra is the second of three dark themed Ionian Champion, the first being and the third .
- Syndra's dance is based on the choreography for the song here. by (소녀시대: So Nyeo Shi Dae), a popular Korean girl group. A side-by-side comparison video can be seen
- Syndra was the third champion to have a difficulty rating of 100, the first being , the second being , and the fourth being . However, her difficulty rating has since fallen to 80. On release, her difficulty rating was 90.
- Each of Syndra's abilities gain new graphical details when levelled to max rank. Dark Sphere gains a darker shockwave color (red for Classic skin, orange-gold for Justicar) and cracks the earth; Force of Will gains a similarly-colored, larger shockwave as well as an energy trail following thrown spheres; Scatter the weak gains a similarly-colored energy wave and electrical jolts; when attaining the max rank of Unleashed Power, the three orbs floating around Syndra will have a slight change of appearance and will leave a trail.
- Syndra is the second champion speculated to be omnipotent, or nearly so. The first one was Xerath.
- However, much like Xerath himself, she is still severely limited
- As seen in this video, Syndra appears to be able to use the balls from another Syndra.
- The fact that Syndra's ultimate (Ultimate Power) can use up to seven balls is possibly a reference to Dragon Ball as there are seven Dragon Balls.
- Syndra is the second of three dark themed champions to have a light themed skin, with being the first and being the third.
- Syndra's parents were not magical, but she doesn't know too much of her family history.
- She's essentially attuned to the flows of magic - she can manifest force just by willing it, and she condenses spheres of raw magic from the air. She doesn't fully understand her talents, and up until now, she hasn't cared about their source. If she wants to realize her full potential, she'll have to understand herself. 
- Her headpiece is Ionian in nature, but unlike the crests that other Ionian characters keep behind them, Syndra placed hers front and center, emblematic of her rejection of restraint.
- Sovereign in her name, has a number of meanings. Her story is about asserting control over things that were held from her - her own fate, her magical ability, her current home and fortress. Sovereign also implies a degree of supremacy, which she believes she has because of her power and her position in the world, literally and symbolically. 
- Syndra is the second champion to have quotes when she levels up an ability, the first being Silver Bolts. upon leveling
- Syndra shares a quote with : "By force of will".
- Syndra's joke is a
- The primary play on words is regarding her lore where she was deemed mentally unbalanced by her Ionian elders (as balance is a defining virtue in Ionian culture), and stands upon on her dark spheres to prove that she "has balance."
- It also refers to Syndra's champion balance as she was reportedly overpowered during development.
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- Syndra's name and appearance shares some similarities with Sindel from the Mortal Kombat franchise.
- Her space-manipulating powers and white hairs are similar to those of from Final Fantasy VIII.
- Her helm is similar to Midna's from The Legend of Zelda: Twilight Princess series.
- In addition, it also looks like the "Mantle of Decorum", Ionia's highest decoration. However, it is placed on her forehead instead of floating behind her head, as a sort of symbol of power, much like a crown.
- In her earlier designs, she was intended to have a Mantle of Decorum; however, this was most likely removed because it contradicts with established lore: the Mantles of Decorum are reserved only for Ionia's most revered and respected people.
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- It is possibly a version of Syndra from an alternate history, where she instead embraced her elders' teaching and became a force for good. This theory is based on her warmer color scheme, use of white feathers and golden spheres. Her helmet also resembles the sun, a symbol of divinity, and her spheres contain images that resemble a "Mantle of Decorum".
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- Syndra shares the Atlantean theme with Fizz.
- Though their paths have been different, and Syndra have similar goals. Both believe the 'balance' that has maintained Ionia for so long must crumble for Ionia's people to come into their own and realize their full potential. Syndra might take interest in Zed's power, and given the right circumstances, an alliance between the two could "tip the scales" in Ionia all the more.
- Due to working for the Ionian Elders,
is Syndra's rival.
- Being an Elder herself, is considered a rival as well.
- Syndra sympathizes with and is intrigued by the power he's obtained, but Xerath would possibly be more interested in her. All of his power is arcane, researched and developed, while Syndra is more instinctive, her approach may succeed at unbinding him where his has failed.
- She is intrigued by and how a child obtained such powers.
- Syndra probably thinks is kind of laughable. If she got past the cutesy yordle exterior, she'd maybe eventually see Veigar as a worthy mage.